一、基本情況：

羅剛銀，博士，研究員，博士生導師，工程化研究中心副主任，國家創新醫療器械審評專家，蘇州電子協會副理事長。長期從事器官再生、光學成像、圖像處理/人工智能算法等方向的研究。

近年來作為項目負責人和課題負責人承擔了20餘項國家及企業課題的研究，包括國家重點研發計劃子課題、國家科技支撐計劃項目、國家863項目子課題、中科院先導A類項目、江蘇省科技支撐項目、蘇州市醫療器械專項、企業委托項目等。

二、主要研究領域及學術成就：

1．器官再生方向：構建基于腫瘤和iPSC的腦、心、肝和腫瘤類器官體系及其藥篩應用研究；開展器官再生所需水凝膠、生物活性材料、結構支撐材料研究；類器官長時程功能維持與多模傳感檢測技術；體外肝髒常溫機械灌注維持與再生技術。

2．光學成像方向：開展提升顯微成像分辨率、成像速度及成像維度研究，包括高速振鏡掃描控制、多波長激光耦合、近紅外光譜分析、超分辨顯微成像、圖形三維重建等研究。

3．醫學檢驗方向：長期從事醫學檢驗儀器的自主創新與國産化研究，涉及免疫、分子和細胞等領域的微弱熒光檢測、機械手、變溫調控、圖像識别、定位離心、智能控制與AI算法等。

4．圖像處理/人工智能算法方向：聚焦深度學習與計算機視覺、深度學習與生物樣本成像分析、細胞與類器官的人工智能圖像處理算法等研究工作。

累計申請發明專利80項，授權發明專利25項，授權實用新型專利58項。在Lab on a Chip、Talanta、光學精密工程等發表論文30篇，獲批II類醫療器械注冊證4項。獲蘇州市科技進步獎、蘇州市好青年榮譽稱号。

三、代表性科研成果：

承擔項目情況

1．國家重點研發計劃，全自動智能化高精度熒光檢測系統的研究，課題負責人，2020.5-2023.4，結題

2．國家重點研發計劃，多孔腔鏡手術機器人可靠性設計與系統集成，子課題負責人，2017.7.1-2021.12.31，結題

3．國家重點研發計劃，手術機器人安全性與有效性評估體系研究，子課題負責人，2019.12.1-2022.11.1，結題

4．國家科技支撐計劃，腫瘤靶向治療的病理診斷及療效評估免疫分析系統的研制，子課題負責人，2015 .1-2017.12，結題

5．中科院先導A類項目，器官長時程功能維持與監測，課題負責人，2021.11-2022.12，結題

6．中科院重大科研設備，超分辨顯微光學核心部件工程化開發，項目負責人，2018.1.1-2022.12.31，結題

7．江蘇省科技支撐計劃，基于血型免疫學方法的自動化專用儀器關鍵技術研究及産業化，2013.6-2016，結題

8．吉林省院地合作專項，基于數字微滴技術的核酸檢測系統及通用試劑的産業化，項目負責人，2020.1-2022.6，結題

9．江蘇省科技支撐計劃，基于血型免疫學方法的自動化專用儀器關鍵技術研究及産業化，2013.6-2016，結題

10．蘇州市新冠應急專項，基于恒溫CRISPR法的系列化核酸檢測儀器的研制，2020.3.1-2020.12.31，結題

代表論著

1．Feng, Ruijie; Li, Zeqin; Zhu, Junyan; Zhang, Yayun; Fang, Hao; Xue, Jinbing; Wang, Jinxian; Lyu, Renliang*; Luo, Gangyin*, Synthesis of a biocompatible fluorinated multiblock copolymer surfactant for water-in-fluorocarbon droplets and its application in droplet digital polymerase chain reaction, JOURNAL OF APPLIED POLYMER SCIENCE, 2024.

2．Zhang, Xiaoliang; Wang, Shun; Wang, Jinxian; Sun, Xiaojie; Xue, Jinbing; Wang, Zhenya; Yang, Tianhang; Weng, Liangfei; Wang, Bidou*; Luo, Gangyin*, A ddPCR platform based on a microfluidic chip with a dual-function flow-focusing structure for sample-to-result DNA quantification analysis, LAB ON A CHIP, 2023.

3．Leng, Bing; Jiang, Hao; Wang, Bidou; Wang, Jinxian; Luo, Gangyin*, Deep-Orga: An improved deep learning-based lightweight model for intestinal organoid detection., Computers in biology and medicine, 2023.

4．Wang, Jinxian; Lyu, Xin; Zhang, Xiaoliang; Wang, Shun; Zeng, Wen; Yang, Tianhang*; Wang, Bidou*; Luo, Gangyin*, An approach for integrating droplet generation and detection in digital polymerase chain reaction applications based on a bifunctional microfluidic cross-structure, TALANTA, 2024.

5．Luo, Gangyin; Zhang, Ying; Wang, Shun; Lv, Xinbei; Yang, Tianhang*; Wang, Jinxian*, Establishment and Validation of an Integrated Microfluidic Step Emulsification Chip Supporting Droplet Digital Nucleic Acid Analysis, BIOSENSORS-BASEL, 2023.

6．Li, Zeqin; Ma, Houshi; Guo, Yuxin; Fang, Hao; Zhu, Chunsen; Xue, Jinbin; Wang, Wenzhong; Luo, Gangyin*; Sun, Yi*, Synthesis of uniform Pickering microspheres doped with quantum dot by microfluidic technology and its application in tumor marker, TALANTA, 2023.

7．Zhang, Xiaoliang; Wang, Jinxian; Lyu, Xin; Yang, Tianhang; Liu, Wei; Wang, Bidou*; Luo, Gangyin*, Hundred-micron droplet ejection by focused ultrasound for genomic applications, SENSORS AND ACTUATORS A-PHYSICAL, 2023.

8．Feng, D.; Zhou, C.; Huang, J.; Luo, G*.; Wu, X., Design and Implementation of Gesture Recognition System Based on Flex Sensors, IEEE Sensors Journal, 2023.

9．Liu, H.; Luo, G*., High frequency heat sealing system in-situ power detection device, 2023 2nd International Symposium on Sensor Technology and Control (ISSTC), 2023.

10．Ma, Xiaoyi; Li, Xiaoqiang; Luo, Gangyin*; Jiao, Jin*, DNA-functionalized gold nanoparticles: Modification, characterization, and biomedical applications, FRONTIERS IN CHEMISTRY, 2022.

11．Yang, Tianhang; Wang, Jinxian; Lv, Sining; Li, Songjing*; Luo, Gangyin*, Thermodynamic Characterization of a Highly Transparent Microfluidic Chip with Multiple On-Chip Temperature Control Units, CRYSTALS, 2022.

12．Li, Xiaoqiang; Guo, Zhenzhen; Luo, Gangyin; Miao, Peng*, Fluorescence DNA Switch for Highly Sensitive Detection of miRNA Amplified by Duplex-Specific Nuclease, SENSORS, 2022.

13．Xue, Yuhan; Luo, Gangyin; Liu, Xiang; Xing, Yuan*; Hu, Bo; Liu, Zhenglong, An Analysis on the Engineering Failure of the Wire Rope Used in Surgical Instruments, JOURNAL OF FAILURE ANALYSIS AND PREVENTION, 2022.

14．Zhou Minchao; Wang Zhenya*; Wang Bidou; Luo Gangyin; Ma Siqi, Design of laser scanning confocal spectroscopy system, Optics and Precision Engineering, 2022.

15．Zhang, Jia-Hao; He, Da-Yong; Luo, Gang-Yin; Wang, Bi-Dou; Huang, Jin-Song*, Bidirectional highly-efficient quantum routing in a T-bulge-shaped waveguide*, CHINESE PHYSICS B, 2021.

16．Zhang, Jie; Yan, Jiaqi; Wang, Jinxian; Xu, Jie; Zhao, Yilong; Luo, Gangyin*, Research on Droplet Digital PCR Amplification System, 2021 IEEE 20TH INTERNATIONAL CONFERENCE ON TRUST, SECURITY AND PRIVACY IN COMPUTING AND COMMUNICATIONS (TRUSTCOM 2021), 2021.

17．Zhang, Xiaoliang; Wang, Bidou; Luo, Gangyin, Design of Dyson Flow Cytometry System, Chinese journal of medical instrumentation, 2019.

18．Luo Gangyin; Wang Bidou; Chen Yugi; Zhao Yilong, Design of athermal mid-infrared imaging spectrometer based on Offner scheme, Infrared and Laser Engineering, 2017.

19．Luo Gangyin; Wang Bidou; Chen Yuqi; Zhao Yilong, Design of Visible Near Infrared Imaging Spectrometer on Unmanned Aerial Vehicle, Acta Photonica Sinica, 2017.

20．Wang Lei; Nie Lan-shun; Zhan De-chen; Wang Bi-dou; Luo Gang-yin, Heuristic algorithm for solving multi-project collaborative scheduling problem with activity splitting, Control and Decision, 2017.

21．Luo Gangyin; Wang Bidou; Chen Yuqi; Zhao Yilong, Optical design of confocal system for near infrared fluorescence scanning, Laser and Infrared, 2017.

發明專利

22．羅剛銀、王弼陡、陳月岩、張運平，一種基于灰度分析與種類識别的血型結果識别算法，發明專利，ZL 201310416614.3

23．羅剛銀、王弼陡、徐昊、王磊、劉亮，張運平，具有卡盒位姿調整機構的血型卡離心機，發明專利，ZL 201510906311.9

24．羅剛銀、呂鑫、楊天航、王弼陡、趙義龍，王進賢，一種用于離體器官灌流的恒溫容器，發明專利，ZL 202310171771.6

25．羅剛銀、王弼陡、徐昊、王磊、劉亮、張運平，具有卡盒位姿調整機構的血型卡離心機，發明專利，ZL 201510906311.9

26．羅剛銀、楊天航、王進賢、王弼陡、呂鑫、趙義龍，一種用于器官體外培養和再生的機械灌注系統，發明專利，ZL 202310170168.6

27．羅剛銀、王弼陡、徐昊、王磊、劉亮、張運平，具有自動開蓋機構的孵育機構，發明專利，ZL 201510903573.X

28．羅剛銀、王進賢、劉亮、趙義龍、黃傑、史奉鑫，一種移動擴增底座的